By Nic Lewis
Introduction
An interesting new paper by Marc Lipsitch and co-authors, “Cross-reactive memory T cells and herd immunity to SARS-CoV-2”, has recently been published.[1] It discusses immunological and epidemiological aspects and implications of pre-existing cross-reactive adaptive immune system memory arising from previous exposure to circulating common cold coronaviruses. They argue that key potential impacts of cross- reactive T cell memory are already incorporated into epidemiological models based on data of transmission dynamics, particularly with regard to their implications for herd immunity. I believe that they are mistaken on the herd immunity point, as I will show in this article.
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